Phenotypes Associated with This Genotype

Genotype
MGI:4821303

• Allelic Composition: Msi2^{Gt(Ayu21-T2)Imeg}/Msi2^{Gt(Ayu21-T2)Imeg}
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:162770 )

• fewer than expected mice are produced (no time of death or observation given)

hematopoietic system

decreased hematopoietic stem cell number ( J:162770 )

• mice exhibit a 2- to 3-fold reduction in frequency and absolute number of KLS (c-Kit+Lin-Sca-1+) hematopoietic stem cells compared with wild-type mice

growth/size/body

decreased body size ( J:162770 )

neoplasm

decreased tumor growth/size ( J:162770 )

• transplanted KLS (c-Kit+Lin-Sca-1+) hematopoietic stem cells transfected with BCR-ABL and NUP98-HOXA9 proliferate slower than similarly treated wild-type cells improving host survival