Phenotypes Associated with This Genotype

Genotype
MGI:4821002

• Allelic Composition: F2rl1^tm1Bpd/F2rl1^tm1Bpd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:96312 )

• 20% of mutants are either stillborn or found dead within 48 hours of birth compared to 8.4% of wild-type mice

postnatal lethality, incomplete penetrance ( J:96312 )

• 20% of mutants are either stillborn or found dead within 48 hours of birth compared to 8.4% of wild-type mice

cardiovascular system

abnormal systemic arterial blood pressure ( J:96312 )

• hypotensive response to SLIGRL, a F2rl1(PAR-2) selective activating peptide, is absent

• the hypotensive and bradycardic responses to SFLLRN, a nonselective receptor activating peptide, and to TFLLRNPNDK, a F2r (PAR-1) selective activating peptide, are increased compared to wild-type mice