Mouse Genome Informatics
hm
    Tacr1tm1Sph/Tacr1tm1Sph
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice
• morphine-treated mice lack conditioned place preference unlike wild-type mice
• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice
• on a rotarod
• mice exhibit hyperactivity compared with wild-type mice
• however, hyperactivity is rescued by D-amphetamine or methylphenidate treatment
• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice

nervous system
• mice exhibit reduced basal dopamine efflux in the frontal cortex compared with wild-type mice
• amphetamine-treated mice lack a dopamine response compared with wild-type mice

homeostasis/metabolism
• mice exhibit reduced basal dopamine efflux in the frontal cortex compared with wild-type mice
• amphetamine-treated mice lack a dopamine response compared with wild-type mice
• after a second potassium ion challenge, extracellular noradrenaline level is increased unlike in wild-type mice

integument
• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:171881