Phenotypes Associated with This Genotype

Genotype
MGI:4821000

• Allelic Composition: F2rl1^tm1Bpd/F2rl1^tm1Bpd
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal thermal nociception ( J:127006 )

• absence of F2rl1(PAR2) agonist-induced thermal hyperalgesia

• the thermal hyperalgesia elicited by a mast-cell activator compound 48/80 is reduced in mutants compared to wild-type mice

• mutants exhibit a significantly reduced hyperalgesic response to intraplantar injection of formalin than wild-type mice but the hyperalgesia is not completely abolished