Phenotypes Associated with This Genotype

Genotype
MGI:4820873

• Allelic Composition: Pdpk1^tm1Maka/Pdpk1^tm1Maka; Tg(CAG-cat,-lacZ)11Miya/0; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased pituitary gland apoptosis ( J:162892 )

• mice exhibit increased apoptosis in the pituitary compared with wild-type mice

increased corticotroph apoptosis ( J:162892 )

• mice exhibit a decrease in corticotrophs in the anterior pituitary due to apoptosis unlike in wild-type mice

• however, corticotroph development in the anterior pituitary at E18.5 is normal

increased melanotroph apoptosis ( J:162892 )

• mice exhibit a decrease in melanotrophs in the intermediate pituitary due to apoptosis unlike in wild-type mice

• however, melanotrophs development in the intermediate pituitary at E18.5 is normal

abnormal pituitary intermediate lobe morphology ( J:162892 )

• extremely thin

abnormal neuron physiology ( J:162892 )

• Pomc1 neurons exhibit a blunted influx of calcium ions in response to leptin compared with similarly treated wild-type neurons

homeostasis/metabolism

hypoglycemia ( J:162892 )

decreased circulating corticosterone level ( J:162892 )

• at 16 weeks in fed and fasted states

increased insulin sensitivity ( J:162892 )

decreased response to leptin ( J:162892 )

• following intraperitoneal leptin injection, mice exhibit a lesser decrease in body weight and food intake compared with similarly treated wild-type mice

adipose tissue

increased total body fat amount ( J:162892 )

• especially visceral fat mass

behavior/neurological

increased food intake ( J:162892 )

• food intake is increased compared to in wild-type mice

endocrine/exocrine glands

increased pituitary gland apoptosis ( J:162892 )

• mice exhibit increased apoptosis in the pituitary compared with wild-type mice

increased corticotroph apoptosis ( J:162892 )

• mice exhibit a decrease in corticotrophs in the anterior pituitary due to apoptosis unlike in wild-type mice

• however, corticotroph development in the anterior pituitary at E18.5 is normal

increased melanotroph apoptosis ( J:162892 )

• mice exhibit a decrease in melanotrophs in the intermediate pituitary due to apoptosis unlike in wild-type mice

• however, melanotrophs development in the intermediate pituitary at E18.5 is normal

abnormal pituitary intermediate lobe morphology ( J:162892 )

• extremely thin

cellular

increased pituitary gland apoptosis ( J:162892 )

• mice exhibit increased apoptosis in the pituitary compared with wild-type mice

increased corticotroph apoptosis ( J:162892 )

• mice exhibit a decrease in corticotrophs in the anterior pituitary due to apoptosis unlike in wild-type mice

• however, corticotroph development in the anterior pituitary at E18.5 is normal

increased melanotroph apoptosis ( J:162892 )

• mice exhibit a decrease in melanotrophs in the intermediate pituitary due to apoptosis unlike in wild-type mice

• however, melanotrophs development in the intermediate pituitary at E18.5 is normal