Phenotypes Associated with This Genotype

Genotype
MGI:4820813

• Allelic Composition: Ret^tm2.1Heno/Ret^tm2(RET)Jmi
• Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal enteric neural crest cell migration ( J:135153 )

• a slight delay at E11.5 in the migratory behavior of enteric neural crest-derived cells (ENCDC) at the levels where the migrating wave front advances into the hindgut

• at E12.5-E13.5, the delay in hindgut colonization by ENCDCs is greatly enhanced

• in approximately half of the fetuses, ENCDC colonization was not observed in the distal colon even at E15.5

nervous system

abnormal enteric ganglia morphology ( J:135153 )

• the nuclei were found to be abnormally indented, resulting in multilobular nuclei ganglia

cellular

abnormal enteric neural crest cell migration ( J:135153 )

• a slight delay at E11.5 in the migratory behavior of enteric neural crest-derived cells (ENCDC) at the levels where the migrating wave front advances into the hindgut

• at E12.5-E13.5, the delay in hindgut colonization by ENCDCs is greatly enhanced

• in approximately half of the fetuses, ENCDC colonization was not observed in the distal colon even at E15.5