Phenotypes Associated with This Genotype

Genotype
MGI:4820810

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:161806 )

• most mice are sacrificed within a few weeks of birth with respiratory distress

respiratory system

abnormal lung morphology ( J:161806 )

• in mice surviving to 15 weeks

increased lung adenocarcinoma incidence ( J:161806 )

• in mice surviving to 15 weeks

bronchiolar epithelial hyperplasia ( J:161806 )

• in mice surviving to 15 weeks

bronchial epithelial hyperplasia ( J:161806 )

• in mice surviving to 15 weeks

lung epithelium hyperplasia ( J:161806 )

• mice that survive to 15 weeks exhibit hyperplasia of the lung epithelium in the bronchi, bronchioles, and alveoli unlike wild-type mice

respiratory distress ( J:161806 )

• within a few weeks of birth

neoplasm

increased lung adenocarcinoma incidence ( J:161806 )

• in mice surviving to 15 weeks