Phenotypes Associated with This Genotype

Genotype
MGI:4820796

• Allelic Composition: Milr1^tm1Shib/Milr1^tm1Shib
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mast cell degranulation ( J:161854 )

• stimulation with mAb to Allergin-1 fails to result in a decrease in Fcer1a mediated release of hexosaminidase from Bone marrow?derived cultured mast cells as it does in wild-type

increased susceptibility to type I hypersensitivity reaction ( J:161854 )

• mice challenged with TNP-OVA show significantly lower rectal temperatures than wild-type

• intravenous injection of dinitrophenol-specific IgE mAb followed by challenge with the epicutaneous application of acetone and olive oil alone in the right ear and dinitrofluorobenzene in acetone and olive oil in the left ear results in an increased ear swelling compared to wild-type

hematopoietic system

decreased mast cell degranulation ( J:161854 )

• stimulation with mAb to Allergin-1 fails to result in a decrease in Fcer1a mediated release of hexosaminidase from Bone marrow?derived cultured mast cells as it does in wild-type

cellular

decreased mast cell degranulation ( J:161854 )

• stimulation with mAb to Allergin-1 fails to result in a decrease in Fcer1a mediated release of hexosaminidase from Bone marrow?derived cultured mast cells as it does in wild-type