Phenotypes Associated with This Genotype

Genotype
MGI:4819965

• Allelic Composition: Tg(Ckm-PTPRF)13Bbk/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:122895 )

N • blood glucose and serum insulin levels are similar to control

abnormal glucose homeostasis ( J:122895 )

abnormal glycogen homeostasis ( J:122895 )

• muscle glycogen synthesis is slightly decreased

insulin resistance ( J:122895 )

• glucose infusion rate needed to maintain euglycemia is decreased by 37% as compared to control

growth/size/body

growth/size/body region phenotype ( J:122895 )

N • body weight and perigonadal fat pad weight is similar to control

muscle

decreased muscle cell glucose uptake ( J:122895 )

• insulin-stimulated glucose transport into skeletal muscle is impaired by 40-50% as compared to control

• glycolysis in skeletal muscle is impaired

cellular

decreased muscle cell glucose uptake ( J:122895 )

• insulin-stimulated glucose transport into skeletal muscle is impaired by 40-50% as compared to control

• glycolysis in skeletal muscle is impaired