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Phenotypes Associated with This Genotype
Genotype
MGI:4819724
Allelic
Composition
Tg(Myh6-TNNT2*R141W)#Ajm/0
Genetic
Background
involves: C3H * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 29% of mice die within 1 year and almost all die by 2 years of age

cardiovascular system
• increase in the ventricular weight to body weight ratio compared to age and sex matched controls
• increase in expression of markers of cardiac hypertrophy
• increase in left ventricular end systolic and end diastolic diameters
• increase in the collagen volume fraction
• decrease in left ventricular systolic function

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1D DOID:0110426 OMIM:601494
J:161899


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory