Phenotypes Associated with This Genotype

Genotype
MGI:4819637

• Allelic Composition: Trp53^tm1.1Dgj/Trp53^tm1.1Dgj
• Genetic Background: involves: SKH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:162466 )

• ionizing radiation-exposed mice exhibit decreased apoptosis in the intestine compared with similarly treated wild-type mice and Trp53^tm2.1Dgj homozygotes

decreased cellular sensitivity to ultraviolet irradiation ( J:162466 )

• UV-exposed mice exhibit decreased apoptosis in the skin compared with similarly treated Trp53^tm2.1Dgj homozygotes

• however, there is no difference compared with wild-type mice

neoplasm

neoplasm ( J:162466 )

N • mice exhibit normal spontaneous and UV-induced tumorigenesis