Phenotypes Associated with This Genotype

Genotype
MGI:4819611

• Allelic Composition: Smarca4^tm1Mag/Smarca4⁺
• Genetic Background: involves: 129S/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:66861 )

• heterozygous pups survive at less than the expected 1:2:1 ratio

postnatal lethality, incomplete penetrance ( J:66861 )

• some heterozygous pups die immediately after birth

nervous system

exencephaly ( J:66861 )

• exencephaly is observed in some heterozygous embryos (5/36) at E16.5-E18.5

neoplasm

increased tumor incidence ( J:66861 )

• differentiated epithelial tumors are observed in some 16+ month old mice (3/20)

• large subcutaneous tumors appear in neck or inguinal regions