About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4819494
Allelic
Composition		 Ccl2tm1Rol/Ccl2tm1Rol
Tg(PMP22)C61Clh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (25 available)
Tg(PMP22)C61Clh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
demyelination ( J:158350 )
• myelin phenotype is improved compared to in Tg(PMP22)C61Clh mice
abnormal action potential ( J:158350 )
• mice exhibit a reduced amplitude of compound action potential and a prolonged duration compared with wild-type mice but not as severely as in Tg(PMP22)C61Clh mice
decreased nerve conduction velocity ( J:158350 )
• not as severely as in Tg(PMP22)C61Clh mice

behavior/neurological
abnormal grip strength ( J:158350 )
• grip strength is improved compared to in Tg(PMP22)C61Clh mice

immune system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

hematopoietic system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory