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Phenotypes Associated with This Genotype
Genotype
MGI:4819493
Allelic
Composition		 Ccl2tm1Rol/Ccl2+
Tg(PMP22)C61Clh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (23 available)
Tg(PMP22)C61Clh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
demyelination ( J:158350 )
• myelin phenotype is improved compared to in Tg(PMP22)C61Clh mice

behavior/neurological

immune system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

hematopoietic system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory