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Phenotypes Associated with This Genotype
Genotype
MGI:4819237
Allelic
Composition		 \Irf1tm1Mak/\Irf1tm1Mak
\Tg(HRAS)2Jic/?
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf1tm1Mak mutation (1 available); any Irf1 mutation (20 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:55418 )
• 44% develop tumors as compared to 7% of controls
increased hemangiosarcoma incidence ( J:55418 )
• angiosarcomas observed most frequently

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory