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Phenotypes Associated with This Genotype
Genotype
MGI:4819227
Allelic
Composition
Id4tm1Fsky/Id4tm1Fsky
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id4tm1Fsky mutation (2 available); any Id4 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by 5 weeks

skeleton
N
• mice did not exhibit skeletal deformities
• the sixth lumbar vertebrae exhibits decreased bone volume compared with wild-type mice
• osteoid thickness in the lateral calvarial bone is reduced compared to in wild-type mice
• the number of two II osteoblast is decreased while the number of type IV osteoblasts is increased compared to in wild-type mice
• however, the total number of ostoblasts is normal
• the growth plate width and longitudinal growth rate is decreased compared to in wild-type mice
• mineral apposition rate of the calvaria bone is reduced compared to in wild-type mice
• lumbar and calvaria bones exhibit reduced bone formation to bone surface ratio compared with wild-type mice

adipose tissue
• the number of adipocytes in the epiphyseal tibia bone marrow is increased compared to in wild-type mice
• the number of adipocytes in the lateral calvaria bone is increased compared to in wild-type mice

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteoporosis 166710 J:162236


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory