Mouse Genome Informatics
hm
    Id4tm1Fsky/Id4tm1Fsky
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die by 5 weeks

skeleton
N
• mice did not exhibit skeletal deformities (J:162236)
• the sixth lumbar vertebrae exhibits decreased bone volume compared with wild-type mice
• osteoid thickness in the lateral calvarial bone is reduced compared to in wild-type mice
• the number of two II osteoblast is decreased while the number of type IV osteoblasts is increased compared to in wild-type mice
• however, the total number of ostoblasts is normal
• the growth plate width and longitudinal growth rate is decreased compared to in wild-type mice
• lumbar and calvaria bones exhibit reduced bone formation to bone surface ratio compared with wild-type mice
• mineral apposition rate of the calvaria bone is reduced compared to in wild-type mice

adipose tissue
• the number of adipocytes in the epiphyseal tibia bone marrow is increased compared to in wild-type mice
• the number of adipocytes in the lateral calvaria bone is increased compared to in wild-type mice

growth/size/body

Mouse Models of Human Disease
OMIM IDRef(s)
Osteoporosis 166710 J:162236