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Phenotypes Associated with This Genotype
Genotype
MGI:4819110
Allelic
Composition
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
involves: C57BL/6J
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phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

immune system

nervous system
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

cardiovascular system
• amyloid-laden vessels show a severe loss of smooth muscle cells
• fresh hemorrhages, as well as indications of previous hemorrhages are found

muscle
• amyloid-laden vessels show a severe loss of smooth muscle cells

cellular
• an irregular thickening of the basement membrane with amorphous material in some vessels
• amyloid fibrils within the basement membrane, predominantly on the adventitial side

homeostasis/metabolism
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral amyloid angiopathy DOID:9246 OMIM:105150
OMIM:117300
OMIM:176500
OMIM:605714
J:92796 , J:162531


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory