Mouse Genome Informatics
tg
    Tg(Thy1-AppDutch)#Jckr/0
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system

immune system

nervous system
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

other phenotype
• an irregular thickening of the basement membrane with amorphous material in some vessels
• amyloid fibrils within the basement membrane, predominantly on the adventitial side
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

cardiovascular system
• amyloid-laden vessels show a severe loss of smooth muscle cells
• fresh hemorrhages, as well as indications of previous hemorrhages are found

muscle
• amyloid-laden vessels show a severe loss of smooth muscle cells

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:92796 , J:162531