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Phenotypes Associated with This Genotype
Genotype
MGI:4819110
Allelic
Composition
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
involves: C57BL/6J
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

immune system

nervous system
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels (J:162531)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels (J:162531)

cardiovascular system
• amyloid-laden vessels show a severe loss of smooth muscle cells (J:92796)
• amyloid-laden vessels show a severe loss of smooth muscle cells (J:92796)
• fresh hemorrhages, as well as indications of previous hemorrhages are found (J:92796)
• fresh hemorrhages, as well as indications of previous hemorrhages are found (J:92796)

muscle
• amyloid-laden vessels show a severe loss of smooth muscle cells (J:92796)
• amyloid-laden vessels show a severe loss of smooth muscle cells (J:92796)

cellular
• an irregular thickening of the basement membrane with amorphous material in some vessels (J:92796)
• amyloid fibrils within the basement membrane, predominantly on the adventitial side (J:92796)
• an irregular thickening of the basement membrane with amorphous material in some vessels (J:92796)
• amyloid fibrils within the basement membrane, predominantly on the adventitial side (J:92796)

homeostasis/metabolism
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels (J:162531)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels (J:162531)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:92796 , J:162531


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory