Mouse Genome Informatics
tg
    Tg(Prnp-APP*)1Hmor/0
B6.Cg-Tg(Prnp-APP*)1Hmor
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• no amyloid plaques are observed unlike in Tg(APPSWE)2576Kha mice (J:159623)
• at 12 months
• at 18 months
• mice exhibit an intraneuronal accumulation of APP oligomers in the cerebral cortex, hippocampus, and cerebellum unlike in Tg(APPSWE)2576Kha or Tg(Prnp-APP)#Hmor mice
• at 24 months, fewer neurons are found in the hippocampal CA3 region compared to in wild-type mice

behavior/neurological
• mice exhibit increased escape latency in a Morris water maze compared with Tg(Prnp-APP)#Hmor and wild-type mice

immune system
• at 12 months

hematopoietic system
• at 12 months

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:159623