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Phenotypes Associated with This Genotype
Genotype
MGI:4818894
Allelic
Composition
Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc
Hoxc8tm2.1(cre)Mrc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8tm3.1(IRES-rtTA2*M2)Mrc mutation (0 available); any Hoxb8 mutation (8 available)
Hoxc8tm2.1(cre)Mrc mutation (0 available); any Hoxc8 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• excessive grooming behavior is not observed in mutants
• mutants have significantly greater latency time in response to heat

nervous system
• reduction in numbers interneurons in laminae I and II are detected, based on labeling for calbindin and calretinin
• in adult animals, significant decrease in neuronal cell body numbers is detected relative to wild-type controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory