Phenotypes Associated with This Genotype

Genotype
MGI:4818891

• Allelic Composition: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}/Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}; Tg(Tek-cre)1Arnd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:162102 )

N • heat insensitivity is not observed in mutants

increased grooming behavior ( J:162102 )

• animals show significantly lengthened grooming times compared to wild-type controls with deletion of Hoxb8 in hematopoietic system; behavior is comparable to complete Hoxb8 null animals

nervous system

nervous system phenotype ( J:162102 )

N • morphology of dorsal spinal cord laminae I and II appears normal, based on labeling for interneurons

integument

focal hair loss ( J:162102 )

• hairless patches develop in most animals due to excessive grooming