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Phenotypes Associated with This Genotype
Genotype
MGI:4818890
Allelic
Composition
Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8tm1.1Mrc mutation (0 available); any Hoxb8 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hair removal in mutants is done with teeth rather than paw scratching; time spent engaged in scratching behavior is similar between controls and most mutants
• mutants spend about twice as much time in grooming in a 24 hour period compared to controls
• lidocaine treatment of mutants does not alter overgrooming, indicating that behavior is not result of response to chronic itching
• mutants have significantly greater latency time in response to heat
• nociceptive defect is not rescued by transplantation of wild-type bone marrow into irradiated mutants

nervous system
• a 15% reduction in the total number of microglia is observed in homozygotes compared to controls
• disorganization and reduction in numbers of input sensory fibers and of interneurons in laminae I and II are detected
• in adult animals, significant decrease in neuronal cell body numbers is detected relative to wild-type controls

immune system
• a 15% reduction in the total number of microglia is observed in homozygotes compared to controls

hematopoietic system
• a 15% reduction in the total number of microglia is observed in homozygotes compared to controls

integument
• hair removal progresses along ventral surface and extends to lateral surfaces with excessive grooming
• result from excessive grooming on ventral surface of body and extending to lateral surfaces


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory