behavior/neurological
• hair removal in mutants is done with teeth rather than paw scratching; time spent engaged in scratching behavior is similar between controls and most mutants
|
• mutants spend about twice as much time in grooming in a 24 hour period compared to controls
• lidocaine treatment of mutants does not alter overgrooming, indicating that behavior is not result of response to chronic itching
|
• mutants have significantly greater latency time in response to heat
• nociceptive defect is not rescued by transplantation of wild-type bone marrow into irradiated mutants
|
nervous system
• a 15% reduction in the total number of microglia is observed in homozygotes compared to controls
|
• disorganization and reduction in numbers of input sensory fibers and of interneurons in laminae I and II are detected
• in adult animals, significant decrease in neuronal cell body numbers is detected relative to wild-type controls
|
immune system
• a 15% reduction in the total number of microglia is observed in homozygotes compared to controls
|
hematopoietic system
• a 15% reduction in the total number of microglia is observed in homozygotes compared to controls
|
integument
• hair removal progresses along ventral surface and extends to lateral surfaces with excessive grooming
|
skin lesions
(
J:162102
)
• result from excessive grooming on ventral surface of body and extending to lateral surfaces
|