Phenotypes Associated with This Genotype

Genotype
MGI:4818470

• Allelic Composition: Tg(APOE-SGMS2)#Jia/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:162192 )

• whether mice are fed a high-fat diet or chow, plasma ApoE levels are decreased compared to in wild-type mice

abnormal sphingomyelin level ( J:162192 )

• liver sphingomyelin (SM) levels are increased compared to in wild-type mice

• sphingosine-1-phosphate levels in the liver are increased compared to in wild-type mice

• liver ceramide levels are decreased compared to in wild-type mice

• mice fed a high cholesterol diet exhibit an increase in plasma SM (HDL and non-HDL) levels compared with similarly treated wild-type mice

liver/biliary system

abnormal hepatocyte physiology ( J:162192 )

• hepatocytes are more sensitive to lysenin-mediated cytolysis than wild-type cells