Phenotypes Associated with This Genotype

Genotype
MGI:4818441

• Allelic Composition: Tg(DBH-PTPN11)33Bmas/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:80747 )

N • number, size and density of neurons is similar to controls

N • neuronal survival, initial axon growth and ability to reach target organs is similar to controls

abnormal sympathetic neuron innervation pattern ( J:80747 )

• submaxillary and pineal glands have increased numbers of sympathetic fibers resulting in increased terminal innervation of target organs as compared to wild-type transgenic control and non-transgenic control

• immunofluorescent staining of fibers is more intense and widely distributed than control

abnormal neurite morphology ( J:80747 )

• cultured superior cervical ganglia (SCG) neurons rarely extend neurites

• neurites that are formed are extremely short (length is 5% of control)