Phenotypes Associated with This Genotype

Genotype
MGI:4818415

• Allelic Composition: Klf4^tm1Khk/Klf4^tm1Khk; Tg(ED-L2-cre)267Jkat/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal tongue squamous epithelium morphology ( J:161868 )

• hypertrophy is observed at 6 months

abnormal esophageal epithelium morphology ( J:161868 )

• at 5 weeks, esophageal epithelia display hypertrophy with altered keratinocyte morphology with phenotype being stronger at 3 months

• at 6 months, a range of phenotypes from hyperplasia to moderate dysplasia with loss of surface keratinization

• basal cells show nuclear distortion and superficial cells have increased nuclear to cytoplasmic ratios, suggesting incomplete differentiation

• BrdU labeling shows increased number of proliferating cells in the basal layer, with a 1.9-fold increased measured at 3 months; compared to controls, increased apoptosis (2.7-fold) in esophageal epithelia is seen at 3 months

craniofacial

abnormal tongue squamous epithelium morphology ( J:161868 )

• hypertrophy is observed at 6 months

integument

focal ventral hair loss ( J:161868 )

• seen at 6 months where skin lesions occur

abnormal skin morphology ( J:161868 )

• hypertrophy is observed in squamous epithelium of skin on the ventral neck

• epithelia of skin on forestomach and back is normal at 6 months

abnormal keratinocyte morphology ( J:161868 )

abnormal keratinocyte differentiation ( J:161868 )

• seen in esophageal epithelia at 5 weeks

skin lesions ( J:161868 )

• lesions (with crusting and moistness) are observed on parts of the face and skin on the ventral surface of the neck at 6 months

cellular

abnormal keratinocyte differentiation ( J:161868 )

• seen in esophageal epithelia at 5 weeks

growth/size/body

abnormal tongue squamous epithelium morphology ( J:161868 )

• hypertrophy is observed at 6 months