Phenotypes Associated with This Genotype

Genotype
MGI:4818350

• Allelic Composition: \Fgf7^tm1Efu/\Fgf7^tm1Efu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle morphology ( J:161954 )

• at symmetric synapses, synaptic vesicles are smaller than in wild-type mice

abnormal synaptic vesicle number ( J:161954 )

• fewer vesicles are docked at symmetric synapses compared to in wild-type mice

abnormal synaptic vesicle clustering ( J:161954 )

• at P14, vesicle clustering in GABAergic synapses is decreased in the CA3 compared to in wild-type mice

• CA3 pyramidal neurons cultured for 14 days have fewer GABAergic vesicles associated with dendrites compared to in cultured wild-type neurons

• however, vesicle clustering in glutamatergic synapses is normal

decreased miniature inhibitory postsynaptic current frequency ( J:161954 )

• the frequency of miniature inhibitory postsynaptic currents (mIPSCs) is decreased compared to in wild-type hippocampal cultures

• however, the amplitude of mIPSCs is normal