Phenotypes Associated with This Genotype

Genotype
MGI:4462855

• Allelic Composition: Hoxc10^tm1Emca/Hoxc10⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal femur morphology ( J:161095 )

• the posterior muscle attachment region cannot be found

abnormal trochanter morphology ( J:161095 )

• by 4 to 6 weeks postnatally, a moderate ridges (1.3%) develops along the anterior longitudinal line of the shaft of the femur

abnormal pelvic girdle bone morphology ( J:161095 )

• delayed fusion between the pubic and ischial bones at 8+ weeks of age

• 4% of the mice show posterior complete dyssymphysis of ischium and pubis

• 44% of the mice show a prominent seam or indentation on the posterior edge of the pelvis vs. 16.7% in wild-type

thoracic vertebral transformation ( J:161095 )

• posterior transformation of the most caudal thoracic vertebra into a lumbar identity

• T12(T13/L1)L5S5 pattern in 38.9% of mutant mice

• the transition occurs at the ninth thoracic vertebra (T9), instead of T10 in 9.3% mice

• T12(T13/L1)L5(L6/S1)S4 pattern in 1.9% of mutant mice

lumbar vertebral transformation ( J:161095 )

• the most caudal lumbar vertebra often undergoes a similar transformation into a sacral (S1) identity

• T13L5(L6/S1)S4 pattern in 7.4% of mutant mice

• T13L5S5 pattern in 31.5% of mutant mice

• T12(T13/L1)L5(L6/S1)S4 pattern in 1.9% of mutant mice

limbs/digits/tail

abnormal femur morphology ( J:161095 )

• the posterior muscle attachment region cannot be found

abnormal trochanter morphology ( J:161095 )

• by 4 to 6 weeks postnatally, a moderate ridges (1.3%) develops along the anterior longitudinal line of the shaft of the femur