Phenotypes Associated with This Genotype

Genotype
MGI:4462796

• Allelic Composition: Glul^tm3Whla/Glul^tm1Whla; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:162067 )

• born in normal numbers

• none found at 6-8 days of age

• death at 2-3 days of age

behavior/neurological

abnormal food intake ( J:162067 )

• nursed immediately after birth but milk intake then declined

nervous system

abnormal brain morphology ( J:162067 )

• moderately elevated brain ammonia levels

• no gross brain malformations

homeostasis/metabolism

decreased alanine level ( J:162067 )

• decreased alanine in the cortex of the brain at two days of age

decreased glutamine level ( J:162067 )

• decreased glutamine in the cortex of the brain at two days of age

increased glycine level ( J:162067 )

• increased glycine in the cortex of the brain at two days of age

abnormal ammonia homeostasis ( J:162067 )

• moderately elevated brain ammonia levels

decreased circulating glucose level ( J:162067 )

• blood glucose levels at 30% of controls at 2 days of age