Analysis Tools
behavior/neurological
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• mice spend a decreased proportion of time in the center of the open field test
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• although not statistically significant, 20 week old mice exhibited hyper-responsiveness to both the hotplate and tail flick tests
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• in response to the cage-top hang test, 20 week old mice easily fall off the cage-top
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• decreased forelimb grip strength
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• shortened stance
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• increased motor activity as determined by number of interruptions to photo cell beams
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• mice exhibit a shorter, wider gait and an increased sway distance
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• decreased rearing behavior at 10 and 20 weeks, although behavior is similar to controls at 5 weeks
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• mice exhibit overtly active, wild running behavior
• mice exhibit increased motor activity at 5 and 10 weeks, but behave similarly to controls by 20 weeks
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• transgenics are socially dominant compared to nontransgenics as determined by the tube test
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liver/biliary system
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• hepatocytes contain a large nucleus altering the nucleus:cytoplasm ratio, however, levels of liver enzymes are similar to controls
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growth/size/body
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• proportionally decreased head and body size as compared to controls
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• mice exhibit decreased body weight up to 20 weeks of age, but weight is similar to controls at 30 weeks
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• mice exhibit decreased body length up to 20 weeks of age, but are similar to controls at 30 weeks
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• males exhibit greater growth retardation than females
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reproductive system
