Phenotypes Associated with This Genotype

Genotype
MGI:4461941

• Allelic Composition: Olfm4^tm1Gpro/Olfm4^tm1Gpro
• Genetic Background: involves: 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

stomach inflammation ( J:161279 )

• following Helicobacter pylori oral challenge

abnormal cytokine level ( J:161279 )

• H-Ala-D-g-Glu-diaminopimelic acid (DAP)- and muramyl dipeptide (MDP)-treated mice exhibit an increase in CCL2 (MCP-1) compared with similarly treated wild-type mice

• DAP-treated mice exhibit increased CCL3 (MIP-1alpha) compared with similarly treated wild-type mice

increased circulating interleukin-12 level ( J:161279 )

• in H-Ala-D-g-Glu-diaminopimelic acid (DAP)- and muramyl dipeptide (MDP)-treated mice

increased circulating interleukin-3 level ( J:161279 )

• in H-Ala-D-g-Glu-diaminopimelic acid (DAP)- and muramyl dipeptide (MDP)-treated mice

increased susceptibility to bacterial infection ( J:161279 )

• following Helicobacter pylori oral challenge, mice exhibit increased infiltration of inflammatory cells in the gastric mucosa compared with wild-type mice

digestive/alimentary system

digestive/alimentary phenotype ( J:161279 )

N • mice exhibit normal gastrointestinal tract development

abnormal gut flora balance ( J:161279 )

• following oral challenge, mice exhibit reduced colonization by Helicobacter pylori and increased infiltration of inflammatory cells in the gastric mucosa compared with wild-type mice

stomach inflammation ( J:161279 )

• following Helicobacter pylori oral challenge

homeostasis/metabolism

abnormal cytokine level ( J:161279 )

• H-Ala-D-g-Glu-diaminopimelic acid (DAP)- and muramyl dipeptide (MDP)-treated mice exhibit an increase in CCL2 (MCP-1) compared with similarly treated wild-type mice

• DAP-treated mice exhibit increased CCL3 (MIP-1alpha) compared with similarly treated wild-type mice

increased circulating interleukin-12 level ( J:161279 )

• in H-Ala-D-g-Glu-diaminopimelic acid (DAP)- and muramyl dipeptide (MDP)-treated mice

increased circulating interleukin-3 level ( J:161279 )

• in H-Ala-D-g-Glu-diaminopimelic acid (DAP)- and muramyl dipeptide (MDP)-treated mice

hematopoietic system

hematopoietic system phenotype ( J:161279 )

N • mice exhibit normal hematopoiesis