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Phenotypes Associated with This Genotype
Genotype
MGI:4461807
Allelic
Composition
Fgfr2m1Sgg/Fgfr2+
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2m1Sgg mutation (0 available); any Fgfr2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• at 3 weeks of age, mice exhibit short snout, retruded mid-face, and variable septal deviation unlike wild-type mice
• sutural spaces are wider than in wild-type mice
• premature fusion in some mice
• mice exhibit decreased antero-posterior skull length compared with wild-type mice
• mice exhibit a delay in horizontal secondary palate formation in the posterior edge of the maxillary bone and hard tissue clefts on the secondary palate compared with wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

growth/size/body
N
• 3 weeks postnatal, mice exhibit normal body size and weight
• mice exhibit a delay in horizontal secondary palate formation in the posterior edge of the maxillary bone and hard tissue clefts on the secondary palate compared with wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

digestive/alimentary system
• mice exhibit a delay in horizontal secondary palate formation in the posterior edge of the maxillary bone and hard tissue clefts on the secondary palate compared with wild-type mice

embryogenesis

hearing/vestibular/ear
• the ear capsule is reduced in size compared to in wild-type mice

respiratory system
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

skeleton
• sutural spaces are wider than in wild-type mice
• premature fusion in some mice
• mice exhibit decreased antero-posterior skull length compared with wild-type mice
• fewer Runx2+ cells are found surrounding the edge of the coronal sutures compared to in wild-type mice
• pericellular spaces in the nasal septum chondrocytes are bigger than in wild-type mice
• of coronal closure in some mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Crouzon Syndrome 123500 J:160674


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory