Mouse Genome Informatics
hm
    Ttll1tm1Seto/Ttll1tm1Seto
involves: 129S/SvEv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
respiratory system
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice
• mice exhibit a decrease in cilia-driven transport compared with wild-type mice
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice
• mice exhibit coughing or sneezing-like noises unlike wild-type mice
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice

immune system
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice

reproductive system

Mouse Models of Human Disease
OMIM IDRef(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:161297