About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4461790
Allelic
Composition
Ttll1tm1Seto/Ttll1tm1Seto
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttll1tm1Seto mutation (1 available); any Ttll1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice
• mice exhibit a decrease in cilia-driven transport compared with wild-type mice
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice
• mice exhibit coughing or sneezing-like noises unlike wild-type mice

immune system
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice

reproductive system

cellular
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory