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Phenotypes Associated with This Genotype
Genotype
MGI:4461790
Allelic
Composition
Ttll1tm1Seto/Ttll1tm1Seto
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttll1tm1Seto mutation (1 available); any Ttll1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice (J:161297)
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure (J:161297)
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice (J:161297)
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure (J:161297)
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice (J:161297)
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice (J:161297)
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice (J:161297)
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice (J:161297)
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice (J:161297)
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice (J:161297)
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice (J:161297)
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice (J:161297)
• mice exhibit a decrease in cilia-driven transport compared with wild-type mice (J:161297)
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice (J:161297)
• mice exhibit a decrease in cilia-driven transport compared with wild-type mice (J:161297)
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice (J:161297)
• mice exhibit coughing or sneezing-like noises unlike wild-type mice (J:161297)
• mice exhibit coughing or sneezing-like noises unlike wild-type mice (J:161297)

immune system
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice (J:161297)
• mice exhibit an accumulation of mucous in the nasal cavity indicating rhinosinusitis compared with wild-type mice (J:161297)

reproductive system
(J:161297)
(J:161297)

cellular
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice (J:161297)
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure (J:161297)
• mice exhibit loss of axonemal curvature in tracheal epithelial cilia compared with wild-type mice (J:161297)
• however, mice exhibit normal axonemes in tracheal epithelial cilia 9 + 2 structure (J:161297)
(J:161297)
(J:161297)
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice (J:161297)
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice (J:161297)
• mice exhibit loss of beating asymmetry in isolated ATP-reactivated ciliary axonemes and intact tracheal ciliary axonemes compared with wild-type mice (J:161297)
• isolated and intact tracheal ciliary axonemes exhibit a 1.5-fold increase in ciliary beating frequency compared to in wild-type mice (J:161297)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory