Phenotypes Associated with This Genotype

Genotype
MGI:4461164

• Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie
• Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:160543 )

• mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice

immune system

abnormal macrophage physiology ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells

decreased circulating interleukin-6 level ( J:160543 )

• following LPS challenge

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

abnormal chemokine secretion ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less CXCL2 (MIP2) than similarly treated wild-type cells

decreased interleukin-6 secretion ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

decreased susceptibility to endotoxin shock ( J:160543 )

• mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:160543 )

• following LPS challenge

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

hematopoietic system

abnormal macrophage physiology ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells