Phenotypes Associated with This Genotype

Genotype
MGI:4461163

• Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:160543 )

• mice treated with 1 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• Background Sensitivity: mice on a 129S6 background are more sensitive to LPS and D-galactosamine than mice on a C57BL/6 background

immune system

increased susceptibility to endotoxin shock ( J:160543 )

• mice treated with 1 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• Background Sensitivity: mice on a 129S6 background are more sensitive to LPS and D-galactosamine than mice on a C57BL/6 background