Mouse Genome Informatics
involves: 129S6/SvEvTac * Swiss Webster
phenotype observed in females
phenotype observed in males
N normal phenotype
• males and females display a longer latency to reach the escape platform in the reversal phase
• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials
• females but not males display a longer latency to find a hidden platform
• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females
• decrease in rearing frequency in an open field in females
• males fail to show a preference for a stranger mouse over an empty cage

nervous system
• small but significant decrease in males

Mouse Models of Human Disease
Autism 209850 J:153165