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Phenotypes Associated with This Genotype
Genotype
MGI:4461155
Allelic
Composition
Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic
Background
involves: 129S6/SvEvTac * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrcamtm1Gmt mutation (1 available); any Nrcam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• males and females display a longer latency to reach the escape platform in the reversal phase (J:153165)
• males and females display a longer latency to reach the escape platform in the reversal phase (J:153165)
• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials (J:153165)
• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials (J:153165)
• females but not males display a longer latency to find a hidden platform (J:153165)
• females but not males display a longer latency to find a hidden platform (J:153165)
• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females (J:153165)
• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females (J:153165)
• decrease in rearing frequency in an open field in females (J:153165)
• decrease in rearing frequency in an open field in females (J:153165)
• males fail to show a preference for a stranger mouse over an empty cage (J:153165)
• males fail to show a preference for a stranger mouse over an empty cage (J:153165)

nervous system
• small but significant decrease in males (J:153165)
• small but significant decrease in males (J:153165)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:153165


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory