Analysis Tools
renal/urinary system
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• at 20 months, mice exhibit increased apoptosis in the medulla, renal tubules, and glomeruli compared with wild-type mice
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
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• at 20 months
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• at 20 months
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• at 20 months
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• at 20 months, kidneys appear rough and granular, are smaller, weigh less, and are darker than in wild-type mice
• however, kidneys are normal at 10 weeks
• at 20 months, kidneys exhibit accumulation and aggregation of alpha-synuclein and ubiquitinated proteins compared with wild-type
• at 20 months, lipofuscin granules accumulate in the kidneys unlike in wild-type mice
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small kidney
(
J:160542
)
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• at 20 months
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• at 20 months
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• in aged mice
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• at 20 months
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cellular
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• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
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• at 20 months, mice exhibit increased apoptosis in the medulla, renal tubules, and glomeruli compared with wild-type mice
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
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• at 20 months
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• at 20 months
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pigmentation
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• at 20 months, lipofuscin granules accumulate in the kidneys unlike in wild-type mice
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nervous system
| N |
• mice exhibit normal dopaminergic neurons and dopamine turnover
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immune system
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• at 20 months
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homeostasis/metabolism
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• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
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