Phenotypes Associated with This Genotype

Genotype
MGI:4459894

• Allelic Composition: Ing4^Gt(XG370)Byg/Ing4^Gt(XG370)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:161381 )

• to low dosages of LPS

homeostasis/metabolism

increased circulating interleukin-6 level ( J:161381 )

• increased monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated upon activation, normal T-cell expressed and secreted) 6hr after LPS injection

abnormal chemokine level ( J:161381 )

• increased monocyte chemoattractant protein-1 (MCP-1) levels in liver and lung and increased RANTES (regulated upon activation, normal T-cell expressed) in the spleen and lung 6 hrs after LPS injection.

• increased monocyte chemoattractant protein-1 (MCP-1) by peritoneal macrophages cultured with LPS or heat-killed bacteria

increased susceptibility to xenobiotic induced morbidity/mortality ( J:161381 )

• to low dosages of LPS

immune system

increased circulating interleukin-6 level ( J:161381 )

• increased monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated upon activation, normal T-cell expressed and secreted) 6hr after LPS injection

abnormal chemokine level ( J:161381 )

• increased monocyte chemoattractant protein-1 (MCP-1) levels in liver and lung and increased RANTES (regulated upon activation, normal T-cell expressed) in the spleen and lung 6 hrs after LPS injection.

• increased monocyte chemoattractant protein-1 (MCP-1) by peritoneal macrophages cultured with LPS or heat-killed bacteria

increased interleukin-6 secretion ( J:161381 )

• IL6 levels were also elevated in the spleen, liver, and lung

• by peritoneal macrophages cultured with LPS or heat-killed bacteria