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Phenotypes Associated with This Genotype
Genotype
MGI:4459822
Allelic
Composition		 Trim3tm1Mak/Trim3tm1Mak
Genetic
Background		 B6.129P2-Trim3tm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim3tm1Mak mutation (1 available); any Trim3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:161372 )
• resistance to pentylenetetrazol-induced seizures

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:161372 )
• resistance to pentylenetetrazol-induced seizures
decreased miniature inhibitory postsynaptic current amplitude ( J:161372 )
• reduced miniature inhibitory postsynaptic current amplitude in cortical neurons
• miniature inhibitory postsynaptic current frequency is unchanged

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory