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Phenotypes Associated with This Genotype
Genotype
MGI:4459535
Allelic
Composition		 Rnf128tm1Cdon/Rnf128tm1Cdon
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf128tm1Cdon mutation (0 available); any Rnf128 mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased splenocyte proliferation ( J:160681 )
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

immune system
increased splenocyte proliferation ( J:160681 )
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response
increased interferon-gamma secretion ( J:160681 )
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response
increased interleukin-2 secretion ( J:160681 )
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response
abnormal immune tolerance ( J:160681 )
• abnormal antigen-specific CD4+ T cell tolerance

cellular
increased splenocyte proliferation ( J:160681 )
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory