Phenotypes Associated with This Genotype

Genotype
MGI:4459524

• Allelic Composition: Il17rc^tm1Lex/Il17rc^tm1Lex
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal chemokine level ( J:159874 )

• The expression of CXCL1, CXCL2, CCL2, and CCL5, but not CCL20, is significantly reduced

increased interleukin-17 secretion ( J:159874 )

• IL17A producing T cells are significantly increased in inguinal lymph nodes and spleens

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:159874 )

• a delay in disease onset as well as reduced disease severity in the MOG peptide induced EAE

decreased inflammatory response ( J:159874 )

• decrease in the total number of immune cells infiltrating the brain and spinal cord in response to MOG peptide

homeostasis/metabolism

abnormal chemokine level ( J:159874 )

• The expression of CXCL1, CXCL2, CCL2, and CCL5, but not CCL20, is significantly reduced