Analysis Tools
mortality/aging
|
• mice die between E9.5 and E11.5
|
cellular
aneuploidy
(
J:161427
)
|
• in embryonic stem cells without any other chromosome abnormalities
|
|
• embryonic stem cells exhibit telomere elongation with activation of the alternative lengthening of telomere mechanism compared with wild-type cells
|
|
• embryonic stem cells exhibit reduced H3K79 di- and tri-methylation compared with wild-type cells
|
|
• of embryonic stem cells and in focal areas of the embryos
|
|
• of embryonic stem cells
|
embryo
|
• yolk vasculature is underdeveloped and disorganized compared to in wild-type mice
• however, yolk sac vasculature is present and contains primitive erythrocytes
|
|
• of embryonic stem cells and in focal areas of the embryos
|
|
• at E8.5, 15% of mice exhibit developmental arrest unlike wild-type mice
• remaining mice exhibit developmental arrest at E9.5
|
|
• at E9.5
|
growth/size/body
|
• at E9.5
|
|
• at E8.5, 15% of mice exhibit developmental arrest unlike wild-type mice
• remaining mice exhibit developmental arrest at E9.5
|
|
• at E9.5
|
limbs/digits/tail
short tail
(
J:161427
)
|
• stunted at E9.5
|
cardiovascular system
|
• yolk vasculature is underdeveloped and disorganized compared to in wild-type mice
• however, yolk sac vasculature is present and contains primitive erythrocytes
|
|
• at E9.5
|
