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Phenotypes Associated with This Genotype
Genotype
MGI:4459458
Allelic
Composition
EdaTa/Y
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EdaTa mutation (11 available); any Eda mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• accumulation of hair in nasal cavities results in "snuffling"
• medial nasal glands are completely absent
• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally
• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip
• branching of lateral nasal gland 3 is defective at a more rostral location

endocrine/exocrine glands
• medial nasal glands are completely absent
• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally
• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip
• branching of lateral nasal gland 3 is defective at a more rostral location

limbs/digits/tail
• devoid or nearly devoid of hair
• usually a few sharp kinks are seen at the tip

pigmentation
• absence of agouti-banding on dorsal hair results in a dark stripe in that region
• noteably delayed

respiratory system
• accumulation of hair in nasal cavities results in "snuffling"
• medial nasal glands are completely absent
• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally
• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip
• branching of lateral nasal gland 3 is defective at a more rostral location

vision/eye

integument
• absence of agouti-banding on dorsal hair results in a dark stripe in that region
• hair does not develop behind the ears and on the tail
• due to the absence of guard-hairs and zig-zag hairs
• E14-17 embryos lack the complement of prominent hair follicles for this age
• the post-orbital vibrissa is absent
• usually there is one rather than two supra-orbital vibrissae
• noteably delayed
• devoid or nearly devoid of tail rings
• noted a few days after birth

growth/size/body
• accumulation of hair in nasal cavities results in "snuffling"
• medial nasal glands are completely absent
• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally
• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip
• branching of lateral nasal gland 3 is defective at a more rostral location


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory