Phenotypes Associated with This Genotype

Genotype
MGI:4459065

• Allelic Composition: Ret^tm1Heno/Ret^tm2(RET)Jmi
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:159854 )

postnatal lethality, incomplete penetrance ( J:159854 )

• 23% of mice die between P5 and P31

digestive/alimentary system

abnormal feces composition ( J:159854 )

• mice exhibit wet stool weight and water stool content compared with control mice

abnormal defecation ( J:159854 )

• mice exhibit decreased stool frequency compared with control mice

renal/urinary system

renal/urinary system phenotype ( J:159854 )

N • mice exhibit normal kidney development

nervous system

nervous system phenotype ( J:159854 )

N • mice exhibit normal motor innervation

absent enteric neurons ( J:159854 )

• in 8 of 21 mice

embryo

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

growth/size/body

decreased body weight ( J:159854 )

postnatal growth retardation ( J:159854 )

cellular

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice