Phenotypes Associated with This Genotype

Genotype
MGI:4459064

• Allelic Composition: Ret^tm2(RET)Jmi/Ret^{tm3.1(Bcl2l1)Heno}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:159854 )

N • mice exhibit improved survival compared with Ret^tm1Heno/Ret^tm2(RET)Jmi mice

digestive/alimentary system

digestive/alimentary phenotype ( J:159854 )

N • gut motility is normal

nervous system

absent enteric neurons ( J:159854 )

• 1 of 51 mice exhibit aganglionosis compared with wild-type mice

• however, 50 of 51 mice exhibit normal enteric nervous system

embryo

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

cellular

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice