Phenotypes for Ret Tg(CAG-cre/Esr1*)5Amc MGI:4459061 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (53 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (53 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal defecation ( J:159854 )

• tamoxifen-treated mice exhibit decreased stool frequency compared with control mice

• 2 to 5 tamoxifen-treated mice exhibit hard feces that accumulates in the distal colon unlike in control mice

abnormal feces composition ( J:159854 )

• tamoxifen-treated mice exhibit wet stool weight and water stool content compared with control mice

growth/size/body

decreased body weight ( J:159854 )

• in tamoxifen-treated mice

nervous system

abnormal enteric neuron morphology ( J:159854 )

• 40% of tamoxifen-treated mice exhibit reduced enteric neurons compared with similarly treated control mice (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

• tamoxifen-treated mice exhibit fewer NOS-expressing neurons compared to in control mice

• however, 60% of tamoxifen-treated mice exhibit normal enteric nervous system development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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