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Phenotypes Associated with This Genotype
Genotype
MGI:4459013
Allelic
Composition		 Runx1tm1Yg/Runx1tm1Yg
Tg(Runx1-GFP)#Itan/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (34 available)
Tg(Runx1-GFP)#Itan mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal dorsal aorta morphology ( J:160791 )
• mice lack GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice
• mesenchyme beneath the dorsal aorta is compact unlike in wild-type mice

hematopoietic system
abnormal hematopoietic system morphology/development ( J:160791 )
• mice lack GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory