Phenotypes Associated with This Genotype

Genotype
MGI:4458936

• Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:160791 )

• the number of colony forming units in culture (CFU-Cs) produced from E8.5 hematopoietic tissues is decreased 8.8-fold compared to CFU-Cs produced from wild-type tissue

• at E8.5, CFU-C tend to be smaller than wild-type colonies

• the number of CFU-Cs generated from E11.5 yolk sac is decreased 10.1-fold compared to CFU-Cs produced from wild-type tissues

• the number of CFU-Cs generated from E11.5 vitelline and umbilical arteries is decreased 12.8-fold compared to CFU-Cs produced from wild-type tissues

• at E11.5, the number of fetal liver (FL) CFU-Cs is reduced 5.9-fold and the size of colonies is decreased compared to in wild-type mice