Analysis Tools
hearing/vestibular/ear
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• the tectorial membrane is thicker and shorter than in wild-type mice but not as much as in homozygous mice
• the fibrils surrounding the edge of the tectorial membrane are partially disrupted compared to in wild-type mice
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• Kimura's membrane contains loosely packed fibrils compared to in wild-type mice
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• during acoustic stimulation of the stapes, only outer hair cells in the first row exhibit forward transduction unlike in similarly treated wild-type cells
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• in response to an increasing intensity of accoustic stimuli, mice exhibit an increase in cochlear microphonic phase lead unlike in similarly treated wild-type mice
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• heterozygous mice had 25-40 dB ABR threshold elevations relative to wild-type littermates
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• mice exhibit enhanced reverse transduction compared with wild-type mice
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• distortion product otoacoustic emission exhibit elevated thresholds, reduced amplitudes, and higher slopes compared to in wild-type mice
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• mice exhibit partial hearing loss compared with wild-type mice
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nervous system
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• during acoustic stimulation of the stapes, only outer hair cells in the first row exhibit forward transduction unlike in similarly treated wild-type cells
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• in response to an increasing intensity of accoustic stimuli, mice exhibit an increase in cochlear microphonic phase lead unlike in similarly treated wild-type mice
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