Analysis Tools
reproductive system
| N |
• female mice are fertile
|
 |
• at stage IX, mice exhibit multinucleate giant cells that populate the lumen of tubules instead of elongating spermatids as in wild-type mice
|
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• in large cysts but not throughout the testes
|
small testis
(
J:160482
)
|
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• at stage IV, not all spermatids exhibit a flattened acrosome as in wild-type mice and exhibit pre-acrosomal vesicles that fail to fuse
• at stage IX, mice exhibit multinucleate giant cells that populate the lumen of tubules instead of elongating spermatids as in wild-type mice
|
azoospermia
(
J:160482
)
|
|
• no elongated spermatids are found at P30
|
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• during spermiogenesis, mice exhibit multinucleate cysts of syncytia with multiple nulcei within each cyst showing a range of acrosome arrest unlike in wild-type mice
|
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• at the round spermatid stage
• however, meiosis is normal
|
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• round sperm do not mature past step 2 and final arrest occurs at step 6 unlike in wild-type mice
|
endocrine/exocrine glands
small testis
(
J:160482
)
|
|
|
cellular
azoospermia
(
J:160482
)
|
|
• no elongated spermatids are found at P30
|
|
|
• at stage IX, mice exhibit multinucleate giant cells that populate the lumen of tubules instead of elongating spermatids as in wild-type mice
|
|
|
• in large cysts but not throughout the testes
|
