Phenotypes Associated with This Genotype

Genotype
MGI:4457488

• Allelic Composition: Grin1^Rgsc174/Grin1^Rgsc174
• Genetic Background: C57BL/6J-Grin1^Rgsc174

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:160947 )

• mice die from E17 to 4 weeks postnatally

postnatal lethality, incomplete penetrance ( J:160947 )

• mice die from E17 to 4 weeks postnatally

nervous system

abnormal neuron physiology ( J:160947 )

• cultured cortical neurons exhibit higher maximum calcium influx levels than wild-type neurons

• the duration of half-maximal calcium levels are longer than in wild-type neurons