Phenotypes Associated with This Genotype

Genotype
MGI:4457487

• Allelic Composition: Grin1^Rgsc174/Grin1⁺
• Genetic Background: C57BL/6J-Grin1^Rgsc174

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:160947 )

N • mice exhibit normal anxiety in a light-dark transition test and spend the same amount of time in the center of an open field as wild-type mice

abnormal behavioral response to xenobiotic ( J:160947 )

• D,l-methylphenidate hydrochloride (MPH)-treated mice exhibit reduced locomotor activity unlike similarly treated wild-type mice

increased exploration in new environment ( J:160947 )

• mice exhibit increased exploration of a tube filled with marbles compared with wild-type mice

• however, time spent exploring the object is normal

hyperactivity ( J:160947 )

• mice exhibit increased activity in an open field test and home cage during the dark period compared with wild-type mice

• however, mice exhibit normal rest-activity cycles under standard light-dark cycle

abnormal social investigation ( J:160947 )

• mice exhibit reduced exploration interacting with other mice compared with wild-type mice

nervous system

abnormal neuron physiology ( J:160947 )

• more c-Fos immunoreactive cells are found in the prelimbic cortex than in wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:160947 )

• D,l-methylphenidate hydrochloride (MPH)-treated mice exhibit a lesser increase in c-Fos immunoreactive cells in the dorsal striatum than similarly treated wild-type mice

• MPH-treated mice exhibit a decrease in c-Fos immunoreactive cells in the prelimbic cortex compared with similarly treated wild-type mice